Infertile women with mild or minimal endometriosis experience enhanced fecundity with laparoscopic ablation or resection of the lesions. So concluded a three and a half year study which followed 341 infertile women aged 20 to 39 in 25 hospitals throughout Canada for 36 weeks or up to 20 weeks of pregnancy.
All participants were randomly assigned to either a diagnostic-laparoscopy or surgical laparoscopy group. Those in the diagnostic group received no treatment; those in the surgical group underwent resection or ablation of visible lesions by cautery, laser, or a combination.
Not taken into account in the study was the efficacy of treating the large percentage of women with unstaged endometriosis with newer gonadotropin-releasing hormone agonists which, theoretically, could be more effective than ablation or resection. (Gambone J, DeCherney A. NEJM 1997;337:269-270.)
Emergency contraception, to prevent pregnancy after unprotected intercourse, whether provided as needed or in advance, is cost-effective when looking at the cost of treatment and the cost and probability of it actually preventing an unintended pregnancy. The use of both progestin-only (minipills) and a single treatment of emergency contraceptive pills saves $29 - $54 in a publicly funded facility and $119 - $142 in a managed care setting in the averted birth model. A copper-T IUD has no savings, but a cost of $53 and $123 respectively. However, if then used as a contraceptive device, savings exceed cost in only 4 months. (Trussell J, et al AM J Pub Health 1997;87:932-937.)
Mirapax, with the active ingredient pramipexole dihydrochloride, was approved by the FDA on 7/1/97, for treating signs and symptoms of Parkinson's Disease.
Zoloft received supplemental approval on 7/8/97 for the efficacy claim that 50 to 200 mg/day can treat panic disorder.